Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features
نویسندگان
چکیده
منابع مشابه
Ultrasonographic features and clinicopathologic characteristics of macrofollicular variant papillary thyroid carcinoma
Macrofollicular variant papillary thyroid carcinoma (MFV-PTC) is defined as papillary thyroid carcinoma with macrofollicles of >200 μm in more than 50% of the cross-sectional area of the specimen. The aim of this study was to evaluate the clinicopathologic characteristics of the MFV-PTC treated in the Yonsei University College of Medicine.Between September 2007 and July 2012, 18,697 patients wi...
متن کاملMacrofollicular variant of papillary thyroid carcinoma: its clinicopathological features and long-term prognosis.
Macrofollicular variant is a rare entity of papillary carcinoma. We previously demonstrated that this variant accounts for 0.3% of papillary carcinoma in Japan. In this study, we investigated the biological characteristics of 5 cases of macrofollicular variant. We reviewed the diagnosis and clinical course of 5 patients with macrofollicular variant. On preoperative ultrasonographic study, 2 cas...
متن کاملThyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma.
Thyroid follicular adenomas (FA) are encapsulated tumors lacking vascular, capsular or lymphatic invasion and the typical nuclear features of papillary carcinoma (PC). However, some FA demonstrate nuclear atypia reminiscent of either follicular carcinomas (FC) or follicular variant of papillary carcinomas (FVPC), suggesting they may represent precursors of malignant transformation. We hypothesi...
متن کاملThree cases of macrofollicular variant of papillary thyroid carcinoma
The macrofollicular variant of papillary thyroid carcinoma (MFPTC) is a well-established entity with characteristic large follicles containing pale colloid and lined by cells with nuclear features of papillary thyroid carcinoma (PTC). In this study, we present three cases of MFPTC, along with a brief review of the literature. For all three of our cases, the histology of the resected specimen sh...
متن کاملFollicular variant of papillary thyroid cancer: encapsulated, nonencapsulated, and diffuse: distinct biologic and clinical entities.
OBJECTIVE To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. DESIGN Retrospective medical chart review and molecular analysis. SETTING Referral center of a university hospita...
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ژورنال
عنوان ژورنال: Histopathology
سال: 2021
ISSN: 0309-0167,1365-2559
DOI: 10.1111/his.14416